CSF markers of Alzheimer’s pathology and microglial activation are associated with altered white matter microstructure in asymptomatic adults at risk for Alzheimer’s disease

BACKGROUND: The immune response in Alzheimer’s disease (AD) involves activation of microglia which may remove β-amyloid. However, overproduction of inflammatory compounds may exacerbate neural damage in Alzheimer’s disease. AD pathology accumulates years before diagnosis, yet the extent to which neu...

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Udgivet i:J Alzheimers Dis
Main Authors: Melah, Kelsey E, Lu, Sharon Yuan-Fu, Hoscheidt, Siobhan M, Alexander, Andrew L, Adluru, Nagesh, Destiche, Daniel J, Carlsson, Cynthia M, Zetterberg, Henrik, Blennow, Kaj, Okonkwo, Ozioma C, Gleason, Carey E, Dowling, N Maritza, Bratzke, Lisa C, Rowley, Howard A, Sager, Mark A, Asthana, Sanjay, Johnson, Sterling C, Bendlin, Barbara B
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760877/
https://ncbi.nlm.nih.gov/pubmed/26836182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-150897
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