Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder

Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy data obtained...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pagani, Lucia, St. Clair, Patricia A., Teshiba, Terri M., Service, Susan K., Fears, Scott C., Araya, Carmen, Araya, Xinia, Bejarano, Julio, Ramirez, Margarita, Castrillón, Gabriel, Gomez-Makhinson, Juliana, Lopez, Maria C., Montoya, Gabriel, Montoya, Claudia P., Aldana, Ileana, Navarro, Linda, Freimer, Daniel G., Safaie, Brian, Keung, Lap-Woon, Greenspan, Kiefer, Chou, Katty, Escobar, Javier I., Ospina-Duque, Jorge, Kremeyer, Barbara, Ruiz-Linares, Andres, Cantor, Rita M., Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Reus, Victor I., Sabatti, Chiara, Bearden, Carrie E., Takahashi, Joseph S., Freimer, Nelson B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760829/
https://ncbi.nlm.nih.gov/pubmed/26712028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513525113
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