Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder

Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy data obtained...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Pagani, Lucia, St. Clair, Patricia A., Teshiba, Terri M., Service, Susan K., Fears, Scott C., Araya, Carmen, Araya, Xinia, Bejarano, Julio, Ramirez, Margarita, Castrillón, Gabriel, Gomez-Makhinson, Juliana, Lopez, Maria C., Montoya, Gabriel, Montoya, Claudia P., Aldana, Ileana, Navarro, Linda, Freimer, Daniel G., Safaie, Brian, Keung, Lap-Woon, Greenspan, Kiefer, Chou, Katty, Escobar, Javier I., Ospina-Duque, Jorge, Kremeyer, Barbara, Ruiz-Linares, Andres, Cantor, Rita M., Lopez-Jaramillo, Carlos, Macaya, Gabriel, Molina, Julio, Reus, Victor I., Sabatti, Chiara, Bearden, Carrie E., Takahashi, Joseph S., Freimer, Nelson B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760829/
https://ncbi.nlm.nih.gov/pubmed/26712028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513525113
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