HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells

Previously, we reported that HIV-Tat elicits spermine oxidase (SMO) activity upregulation through NMDA receptor (NMDAR) stimulation in human SH-SY5Y neuroblastoma cells, thus increasing ROS generation, which in turn leads to GSH depletion, oxidative stress, and reduced cell viability. In several cel...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Mastrantonio, Roberta, Cervelli, Manuela, Pietropaoli, Stefano, Mariottini, Paolo, Colasanti, Marco, Persichini, Tiziana
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760771/
https://ncbi.nlm.nih.gov/pubmed/26895301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149802
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