Impact of concurrent PIK3CA mutations on response to EGFR tyrosine kinase inhibition in EGFR-mutant lung cancers and on prognosis in oncogene-driven lung adenocarcinomas

INTRODUCTION: In patients with EGFR or KRAS-mutant lung adenocarcinomas, the prognostic impact of a concurrent PIK3CA mutation remains unclear. Although preclinical data suggest that sensitivity to EGFR tyrosine kinase inhibition (TKI) is decreased in EGFR-mutant lung cancers also harboring a PIK3CA...

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Detalhes bibliográficos
Publicado no:J Thorac Oncol
Main Authors: Eng, Juliana, Woo, Kaitlin M., Sima, Camelia S., Plodkowski, Andrew, Hellmann, Matthew D., Chaft, Jamie, Kris, Mark G., Arcila, Maria E., Ladanyi, Marc, Drilon, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760768/
https://ncbi.nlm.nih.gov/pubmed/26334752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000671
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