Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.
Taxol inhibited HeLa cell proliferation by inducing a sustained mitotic block at the metaphase/anaphase boundary. Half-maximal inhibition of cell proliferation occurred at 8 nM taxol, and mitosis was half-maximally blocked at 8 nM taxol. Inhibition of mitosis was associated with formation of an inco...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1993
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47607/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8105478/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.20.9552 |
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