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Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver

While in vitro studies have demonstrated that a glucocorticoid receptor (GR) splice isoform, β-isoform of human GR (hGRβ), acts as a dominant-negative inhibitor of the classic hGRα and confers glucocorticoid resistance, the in vivo function of hGRβ is poorly understood. To this end, we created an ad...

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Publicat a:Mol Cell Biol
Autors principals: He, Bo, Cruz-Topete, Diana, Oakley, Robert H., Xiao, Xiao, Cidlowski, John A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760220/
https://ncbi.nlm.nih.gov/pubmed/26711253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00908-15
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