A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation

The conjugation/de-conjugation of Small Ubiquitin-like Modifier (SUMO) has been shown to be associated with a diverse set of physiologic/pathologic conditions. The clinical significance and ostensible therapeutic utility offered via the selective control of the global SUMOylation process has become...

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Veröffentlicht in:J Cereb Blood Flow Metab
Hauptverfasser: Bernstock, Joshua D, Lee, Yang-ja, Peruzzotti-Jametti, Luca, Southall, Noel, Johnson, Kory R, Maric, Dragan, Volpe, Giulio, Kouznetsova, Jennifer, Zheng, Wei, Pluchino, Stefano, Hallenbeck, John M
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2015
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759677/
https://ncbi.nlm.nih.gov/pubmed/26661196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15609939
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