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Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration
Major depression brings about a heavy socio-economic burden worldwide due to its high prevalence and the low efficacy of antidepressant drugs, mostly inhibiting the serotonin transporter (SERT). As a result, ~80% of patients show recurrent or chronic depression, resulting in a poor quality of life a...
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| Publicado no: | Mol Psychiatry |
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| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4759205/ https://ncbi.nlm.nih.gov/pubmed/26100539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.80 |
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