RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis

Current antidepressants, which inhibit the serotonin transporter (SERT), display limited efficacy and slow onset of action. Here, we show that partial reduction of SERT expression by small interference RNA (SERT-siRNA) decreased immobility in the tail suspension test, displaying an antidepressant po...

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Détails bibliographiques
Auteurs principaux: Ferrés-Coy, A, Pilar-Cuellar, F, Vidal, R, Paz, V, Masana, M, Cortés, R, Carmona, M C, Campa, L, Pazos, Á, Montefeltro, A, Valdizán, E M, Artigas, F, Bortolozzi, A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566716/
https://ncbi.nlm.nih.gov/pubmed/23321808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2012.135
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