RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis

Current antidepressants, which inhibit the serotonin transporter (SERT), display limited efficacy and slow onset of action. Here, we show that partial reduction of SERT expression by small interference RNA (SERT-siRNA) decreased immobility in the tail suspension test, displaying an antidepressant po...

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Dettagli Bibliografici
Autori principali: Ferrés-Coy, A, Pilar-Cuellar, F, Vidal, R, Paz, V, Masana, M, Cortés, R, Carmona, M C, Campa, L, Pazos, Á, Montefeltro, A, Valdizán, E M, Artigas, F, Bortolozzi, A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566716/
https://ncbi.nlm.nih.gov/pubmed/23321808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2012.135
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