Myozap Deficiency Promotes Adverse Cardiac Remodeling via Differential Regulation of Mitogen-activated Protein Kinase/Serum-response Factor and β-Catenin/GSK-3β Protein Signaling

The intercalated disc (ID) is a “hot spot” for heart disease, as several ID proteins have been found mutated in cardiomyopathy. Myozap is a recent addition to the list of ID proteins and has been implicated in serum-response factor signaling. To elucidate the cardiac consequences of targeted deletio...

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Vydáno v:J Biol Chem
Hlavní autoři: Rangrez, Ashraf Yusuf, Eden, Matthias, Poyanmehr, Reza, Kuhn, Christian, Stiebeling, Katharina, Dierck, Franziska, Bernt, Alexander, Lüllmann-Rauch, Renate, Weiler, Hartmut, Kirchof, Paulus, Frank, Derk, Frey, Norbert
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759188/
https://ncbi.nlm.nih.gov/pubmed/26719331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.689620
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