Glycosylphosphatidylinositol Anchor Modification Machinery Deficiency Is Responsible for the Formation of Pro-Prion Protein (PrP) in BxPC-3 Protein and Increases Cancer Cell Motility

The normal cellular prion protein (PrP) is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein. However, in pancreatic ductal adenocarcinoma cell lines, such as BxPC-3, PrP exists as a pro-PrP retaining its glycosylphosphatidylinositol (GPI) peptide signaling sequence. Here, we r...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yang, Liheng, Gao, Zhenxing, Hu, Lipeng, Wu, Guiru, Yang, Xiaowen, Zhang, Lihua, Zhu, Ying, Wong, Boon-Seng, Xin, Wei, Sy, Man-Sun, Li, Chaoyang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759170/
https://ncbi.nlm.nih.gov/pubmed/26683373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.705830
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