p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease

In Alzheimer's disease (AD), neurodegenerative signals such as amyloid-beta (Aβ) and the precursors of neurotrophins, outbalance neurotrophic signals, causing synaptic dysfunction and neurodegeneration. The neurotrophin receptor p75 (p75NTR) is a receptor of Aβ and mediates Aβ-induced neurodege...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Principais autores: Yao, X-Q, Jiao, S-S, Saadipour, K, Zeng, F, Wang, Q-H, Zhu, C, Shen, L-L, Zeng, G-H, Liang, C-R, Wang, J, Liu, Y-H, Hou, H-Y, Xu, X, Su, Y-P, Fan, X-T, Xiao, H-L, Lue, L-F, Zeng, Y-Q, Giunta, B, Zhong, J-H, Walker, D G, Zhou, H-D, Tan, J, Zhou, X-F, Wang, Y-J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759103/
https://ncbi.nlm.nih.gov/pubmed/25917367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.49
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