Endothelial Nitric Oxide Synthase Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-nitrosylation

OBJECTIVE: Dihydrofolate reductase (DHFR) is a key protein involved in tetrahydrobiopterin (BH(4)) regeneration from 7,8-dihydrobiopterin (BH(2)). Dysfunctional DHFR may induce endothelial nitric oxide synthase (eNOS) uncoupling resulting in enzyme production of superoxide anions instead of nitric o...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Cai, Zhejun, Lu, Qiulun, Ding, Ye, Wang, Qilong, Xiao, Lei, Song, Ping, Zou, Ming-Hui
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758687/
https://ncbi.nlm.nih.gov/pubmed/26381869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.305796
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