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Endothelial Nitric Oxide Synthase Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-nitrosylation
OBJECTIVE: Dihydrofolate reductase (DHFR) is a key protein involved in tetrahydrobiopterin (BH(4)) regeneration from 7,8-dihydrobiopterin (BH(2)). Dysfunctional DHFR may induce endothelial nitric oxide synthase (eNOS) uncoupling resulting in enzyme production of superoxide anions instead of nitric o...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4758687/ https://ncbi.nlm.nih.gov/pubmed/26381869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.305796 |
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