Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

Dengue is the most common vector-borne viral disease, causing nearly 400 million infections yearly. Currently there are no approved therapies. Antibody epitopes that elicit weak humoral responses may not be accessible by conventional B cell panning methods. To demonstrate an alternative strategy to...

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Publicado no:Cell
Main Authors: Robinson, Luke N., Tharakaraman, Kannan, Rowley, Kirk J., Costa, Vivian V., Chan, Kuan Rong, Wong, Yee Hwa, Ong, Li Ching, Tan, Hwee Cheng, Koch, Tyree, Cain, David, Kirloskar, Rama, Viswanathan, Karthik, Liew, Chong Wai, Tissire, Hamid, Ramakrishnan, Boopathy, Myette, James R., Babcock, Gregory J., Sasisekharan, V., Alonso, Sylvie, Chen, Jianzhu, Lescar, Julien, Shriver, Zachary, Ooi, Eng Eong, Sasisekharan, Ram
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758460/
https://ncbi.nlm.nih.gov/pubmed/26189681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.06.057
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