Requirement of POL3 and POL4 on non-homologous and microhomology-mediated end joining in rad50/xrs2 mutants of Saccharomyces cerevisiae

Non-homologous end joining (NHEJ) directly joins two broken DNA ends without sequence homology. A distinct pathway called microhomology-mediated end joining (MMEJ) relies on a few base pairs of homology between the recombined DNA. The majority of DNA double-strand breaks caused by endogenous oxygen...

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Publicado en:Mutagenesis
Autores principales: Galli, Alvaro, Chan, Cecilia Y., Parfenova, Liubov, Cervelli, Tiziana, Schiestl, Robert H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757936/
https://ncbi.nlm.nih.gov/pubmed/26122113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gev046
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