The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways

Scleroderma is a group of rare diseases associated with early and transient inflammation and vascular injury, followed by fibrosis affecting the skin and multiple internal organs. Fibroblast activation is the hallmark of scleroderma, and disrupting the intracellular TGFβ signaling may provide a nove...

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Publicat a:Sci Rep
Autors principals: del Río, Carmen, Navarrete, Carmen, Collado, Juan A., Bellido, M. Luz, Gómez-Cañas, María, Pazos, M. Ruth, Fernández-Ruiz, Javier, Pollastro, Federica, Appendino, Giovanni, Calzado, Marco A., Cantarero, Irene, Muñoz, Eduardo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757881/
https://ncbi.nlm.nih.gov/pubmed/26887982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21703
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