VCE‐004.3, a cannabidiol aminoquinone derivative, prevents bleomycin‐induced skin fibrosis and inflammation through PPARγ‐ and CB(2) receptor‐dependent pathways

BACKGROUND AND PURPOSE: The endocannabinoid system and PPARγ are important targets for the development of novel compounds against fibrotic diseases such as systemic sclerosis (SSc), also called scleroderma. The aim of this study was to characterize VCE‐004.3, a novel cannabidiol derivative, and stud...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: del Rio, Carmen, Cantarero, Irene, Palomares, Belén, Gómez‐Cañas, María, Fernández‐Ruiz, Javier, Pavicic, Carolina, García‐Martín, Adela, Luz Bellido, Maria, Ortega‐Castro, Rafaela, Pérez‐Sánchez, Carlos, López‐Pedrera, Chary, Appendino, Giovanni, Calzado, Marco A, Muñoz, Eduardo
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135789/
https://ncbi.nlm.nih.gov/pubmed/30033591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14450
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