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Investigation of allosteric modulation mechanism of metabotropic glutamate receptor 1 by molecular dynamics simulations, free energy and weak interaction analysis
Metabotropic glutamate receptor 1 (mGlu(1)), which belongs to class C G protein-coupled receptors (GPCRs), can be coupled with G protein to transfer extracellular signal by dimerization and allosteric regulation. Unraveling the dimer packing and allosteric mechanism can be of great help for understa...
Sparad:
| I publikationen: | Sci Rep |
|---|---|
| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4757871/ https://ncbi.nlm.nih.gov/pubmed/26887338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21763 |
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