Persistent activation of microglia and NADPH drive hippocampal dysfunction in experimental multiple sclerosis

Cognitive impairment is common in multiple sclerosis (MS). Unfortunately, the synaptic and molecular mechanisms underlying MS-associated cognitive dysfunction are largely unknown. We explored the presence and the underlying mechanism of cognitive and synaptic hippocampal dysfunction during the remis...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Di Filippo, Massimiliano, de Iure, Antonio, Giampà, Carmela, Chiasserini, Davide, Tozzi, Alessandro, Orvietani, Pier Luigi, Ghiglieri, Veronica, Tantucci, Michela, Durante, Valentina, Quiroga-Varela, Ana, Mancini, Andrea, Costa, Cinzia, Sarchielli, Paola, Fusco, Francesca Romana, Calabresi, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757867/
https://ncbi.nlm.nih.gov/pubmed/26887636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20926
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