Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA

The selective targeting of mismatched DNA overexpressed in cancer cells is an appealing strategy in designing cancer diagnosis and therapy protocols. Few luminescent probes that specifically detect intracellular mismatched DNA have been reported. Here we used Pt(II) complexes with luminescence sensi...

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Pubblicato in:Nat Commun
Autori principali: Fung, Sin Ki, Zou, Taotao, Cao, Bei, Chen, Tianfeng, To, Wai-Pong, Yang, Chen, Lok, Chun-Nam, Che, Chi-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757794/
https://ncbi.nlm.nih.gov/pubmed/26883164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10655
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