Hepatitis C virus inhibitor synergism suggests multistep interactions between heat-shock protein 90 and hepatitis C virus replication

AIM: To address the effect of heat-shock protein 90 (HSP90) inhibitors on the release of the hepatitis C virus (HCV), a cell culture-derived HCV (JFH1/HCVcc) from Huh-7 cells was examined. METHODS: We quantified both the intracellular and extracellular (culture medium) levels of the components (RNA...

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Detalhes bibliográficos
Publicado no:World J Hepatol
Main Authors: Kubota, Naoko, Nomoto, Masataka, Hwang, Gi-Wook, Watanabe, Toshihiko, Kohara, Michinori, Wakita, Takaji, Naganuma, Akira, Kuge, Shusuke
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2016
Assuntos:
Basic Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757651/
https://ncbi.nlm.nih.gov/pubmed/26925202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4254/wjh.v8.i5.282
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