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Clinical sequencing: is WGS the better WES?

Current clinical next-generation sequencing is done by using gene panels and exome analysis, both of which involve selective capturing of target regions. However, capturing has limitations in sufficiently covering coding exons, especially GC-rich regions. We compared whole exome sequencing (WES) wit...

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Bibliographic Details
Published in:Hum Genet
Main Authors: Meienberg, Janine, Bruggmann, Rémy, Oexle, Konrad, Matyas, Gabor
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757617/
https://ncbi.nlm.nih.gov/pubmed/26742503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-015-1631-9
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