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AAV9-mediated central nervous system–targeted gene delivery via cisterna magna route in mice
Current barriers to the use of adeno-associated virus serotype 9 (AAV9) in clinical trials for treating neurological disorders are its high expression in many off-target tissues such as liver and heart, and lack of cell specificity within the central nervous system (CNS) when using ubiquitous promot...
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| Publicat a: | Mol Ther Methods Clin Dev |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4756767/ https://ncbi.nlm.nih.gov/pubmed/26942208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.55 |
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