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A minimal conformational switching-dependent model for amyloid self-assembly

Amyloid formation is associated with various pathophysiological conditions like Alzheimer’s and Parkinson’s diseases as well as many useful functions. The hallmark of amyloid assemblies is a conformational transition of the constituent proteins into a β - sheet rich filament. Accounting for this con...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ranganathan, Srivastav, Ghosh, Dhiman, Maji, Samir K, Padinhateeri, Ranjith
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756677/
https://ncbi.nlm.nih.gov/pubmed/26883720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21103
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