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Comparison of Linear and Cyclic HAV Peptides in Modulating the Blood-Brain Barrier Permeability: Impact on Delivery of Molecules to the Brain
The aim of this study is to evaluate the effect of peptide cyclization on the BBB modulatory activity and plasma stability of HAV peptides, which are derived from the EC1 domain of human E-cadherin. The activities to modulate the intercellular junctions by linear HAV4 (Ac-SHAVAS-NH(2)), cyclic cHAVc...
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| Publicado no: | J Pharm Sci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4756412/ https://ncbi.nlm.nih.gov/pubmed/26869430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0022-3549(15)00188-4 |
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