Long-term safety and stability of angiogenesis induced by balanced single-vector co-expression of PDGF-BB and VEGF(164) in skeletal muscle

Therapeutic angiogenesis by growth factor delivery is an attractive treatment strategy for ischemic diseases, yet clinical efficacy has been elusive. The angiogenic master regulator VEGF-A can induce aberrant angiogenesis if expressed above a threshold level. Since VEGF remains localized in the matr...

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Vydáno v:Sci Rep
Hlavní autoři: Gianni-Barrera, Roberto, Burger, Maximilian, Wolff, Thomas, Heberer, Michael, Schaefer, Dirk J., Gürke, Lorenz, Mujagic, Edin, Banfi, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756385/
https://ncbi.nlm.nih.gov/pubmed/26882992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21546
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