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Matrix Rigidity Differentially Regulates Invadopodia Activity Through ROCK1 and ROCK2
ROCK activity increases due to ECM rigidity in the tumor microenvironment and promotes a malignant phenotype via actomyosin contractility. Invasive migration is facilitated by actin-rich adhesive protrusions known as invadopodia that degrade the ECM. Invadopodia activity is dependent on matrix rigid...
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| Yayımlandı: | Biomaterials |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4755854/ https://ncbi.nlm.nih.gov/pubmed/26826790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2016.01.028 |
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