Structure and Functional Characterization of a Bile Acid 7α Dehydratase BaiE in Secondary Bile Acid Synthesis

Conversion of the primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) to the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA) is performed by a few species of intestinal bacteria in the genus Clostridium through a multistep biochemical pathway that removes a 7α...

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Bibliographic Details
Published in:Proteins
Main Authors: Bhowmik, Shiva, Chiu, Hsien-Po, Jones, David H., Chiu, Hsiu-Ju, Miller, Mitchell D., Xu, Qingping, Farr, Carol L., Ridlon, Jason M., Wells, James E., Elsliger, Marc-André, Wilson, Ian A., Hylemon, Phillip B., Lesley, Scott A.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755848/
https://ncbi.nlm.nih.gov/pubmed/26650892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24971
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