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Aldose reductase inhibition suppresses azoxymethane-induced colonic premalignant lesions in C57BL/KsJ-db/db mice

Type-2 diabetes and obesity-related metabolic abnormalities are major risk factors for the development of colon cancer. In the present study, we examined the effects of polyol pathway enzyme aldose reductase (AR) inhibitor, fidarestat, on the development of azoxymethane (AOM)-induced colonic premali...

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Bibliografiske detaljer
Udgivet i:Cancer Lett
Main Authors: Saxena, Ashish, Shoeb, Mohammad, Tammali, Ravinder, Ramana, Kota V., Srivastava, Satish K.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755497/
https://ncbi.nlm.nih.gov/pubmed/25218594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.09.006
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