Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

BACKGROUND: c-Met is the receptor tyrosine kinase for hepatocyte growth factor (HGF) encoded by the MET proto-oncogene. Aberrant activation of c-Met resulting from MET amplification and c-Met overexpression is associated with poor clinical outcome in multiple malignancies underscoring the importance...

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發表在:BMC Cancer
Main Authors: Wang, Jieyi, Goetsch, Liliane, Tucker, Lora, Zhang, Qian, Gonzalez, Alexandra, Vaidya, Kedar S., Oleksijew, Anatol, Boghaert, Erwin, Song, Minghao, Sokolova, Irina, Pestova, Ekaterina, Anderson, Mark, Pappano, William N., Ansell, Peter, Bhathena, Anahita, Naumovski, Louie, Corvaia, Nathalie, Reilly, Edward B.
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755020/
https://ncbi.nlm.nih.gov/pubmed/26879245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2138-z
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