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Statistical Colocalization of Genetic Risk Variants for Related Autoimmune Diseases in the Context of Common Controls

Identifying whether potential causal variants for related diseases are shared can identify overlapping etiologies of multifactorial disorders. Colocalization methods disentangle shared and distinct causal variants. However, existing approaches require independent datasets. Here we extend two colocal...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Fortune, Mary D., Guo, Hui, Burren, Oliver, Schofield, Ellen, Walker, Neil M., Ban, Maria, Sawcer, Stephen J., Bowes, John, Worthington, Jane, Barton, Ann, Eyre, Steve, Todd, John A., Wallace, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754941/
https://ncbi.nlm.nih.gov/pubmed/26053495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3330
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