Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression

Nanoparticle-based delivery of nucleotides offers an alternative to viral vectors for gene therapy. We report highly efficient in vivo delivery of modified mRNA (modRNA) to rat and pig myocardium using formulated lipidoid nanoparticles (FLNP). Direct myocardial injection of FLNP containing 1–10 μg e...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Mol Ther
Päätekijät: Turnbull, Irene C, Eltoukhy, Ahmed A, Fish, Kenneth M, Nonnenmacher, Mathieu, Ishikawa, Kiyotake, Chen, Jiqiu, Hajjar, Roger J, Anderson, Daniel G, Costa, Kevin D
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754552/
https://ncbi.nlm.nih.gov/pubmed/26471463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.193
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