Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression

Nanoparticle-based delivery of nucleotides offers an alternative to viral vectors for gene therapy. We report highly efficient in vivo delivery of modified mRNA (modRNA) to rat and pig myocardium using formulated lipidoid nanoparticles (FLNP). Direct myocardial injection of FLNP containing 1–10 μg e...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Turnbull, Irene C, Eltoukhy, Ahmed A, Fish, Kenneth M, Nonnenmacher, Mathieu, Ishikawa, Kiyotake, Chen, Jiqiu, Hajjar, Roger J, Anderson, Daniel G, Costa, Kevin D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754552/
https://ncbi.nlm.nih.gov/pubmed/26471463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.193
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