Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression

Nanoparticle-based delivery of nucleotides offers an alternative to viral vectors for gene therapy. We report highly efficient in vivo delivery of modified mRNA (modRNA) to rat and pig myocardium using formulated lipidoid nanoparticles (FLNP). Direct myocardial injection of FLNP containing 1–10 μg e...

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Detaylı Bibliyografya
Yayımlandı:Mol Ther
Asıl Yazarlar: Turnbull, Irene C, Eltoukhy, Ahmed A, Fish, Kenneth M, Nonnenmacher, Mathieu, Ishikawa, Kiyotake, Chen, Jiqiu, Hajjar, Roger J, Anderson, Daniel G, Costa, Kevin D
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754552/
https://ncbi.nlm.nih.gov/pubmed/26471463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.193
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