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Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice

The β-lactam antibiotic ceftriaxone (CTX) reduces cocaine reinforcement and relapse in preclinical assays through a mechanism involving activation of glutamate transporter subtype 1 (GLT-1). However, its poor brain penetrability and intravenous administration route may limit its therapeutic utility...

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Foilsithe in:Amino Acids
Main Authors: Kim, Jae, John, Joel, Langford, Dianne, Walker, Ellen, Ward, Sara, Rawls, Scott M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754134/
https://ncbi.nlm.nih.gov/pubmed/26543027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-015-2117-8
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