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Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling
Huntington's disease (HD) is a progressive neurological disorder whose non-motor symptoms include sleep disturbances. Whether sleep and activity abnormalities are primary molecular disruptions of mutant Huntingtin (mutHtt) expression or result from neurodegeneration is unclear. Here, we report...
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| Опубликовано в: : | Hum Mol Genet |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4754039/ https://ncbi.nlm.nih.gov/pubmed/26604145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv482 |
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