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Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling

Huntington's disease (HD) is a progressive neurological disorder whose non-motor symptoms include sleep disturbances. Whether sleep and activity abnormalities are primary molecular disruptions of mutant Huntingtin (mutHtt) expression or result from neurodegeneration is unclear. Here, we report...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Gonzales, Erin D., Tanenhaus, Anne K., Zhang, Jiabin, Chaffee, Ryan P., Yin, Jerry C.P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754039/
https://ncbi.nlm.nih.gov/pubmed/26604145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv482
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