Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation

Aims: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been developed to treat non-small cell lung cancer (NSCLC) patients with EGFR mutation, but TKI resistance is common. Almost half of the acquired resistance patients are due to additional T790M mutation on EGFR (EGF...

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Detalhes bibliográficos
Publicado no:Antioxid Redox Signal
Main Authors: Leung, Elaine Lai-Han, Fan, Xing-Xing, Wong, Maria Pik, Jiang, Zhi-Hong, Liu, Zhong-Qiu, Yao, Xiao-Jun, Lu, Lin-Lin, Zhou, Yan-Ling, Yau, Li-Fong, Tin, Vicky Pui-Chi, Liu, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753639/
https://ncbi.nlm.nih.gov/pubmed/26528827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6420
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