Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists

[Image: see text] 2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound 1, structural modifications were made to obtain highly potent and selective TAAR1 ligands such as 12 (RO5166017), 18 (RO5256390), 36 (RO5203648), and 48 (RO5263...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Galley, Guido, Beurier, Angélica, Décoret, Guillaume, Goergler, Annick, Hutter, Roman, Mohr, Susanne, Pähler, Axel, Schmid, Philipp, Türck, Dietrich, Unger, Robert, Zbinden, Katrin Groebke, Hoener, Marius C., Norcross, Roger D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2015
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753552/
https://ncbi.nlm.nih.gov/pubmed/26985297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00449
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