Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell and patient-derived tumor organoids

There are few in vitro models of exocrine pancreas development and primary human pancreatic adenocarcinoma (PDAC). We establish three-dimensional culture conditions to induce the differentiation of human pluripotent stem cells (PSCs) into exocrine progenitor organoids that form ductal and acinar str...

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Publicado no:Nat Med
Main Authors: Huang, Ling, Holtzinger, Audrey, Jagan, Ishaan, BeGora, Michael, Lohse, Ines, Ngai, Nicholas, Nostro, Cristina, Wang, Rennian, Muthuswamy, Lakshmi B., Crawford, Howard C., Arrowsmith, Cheryl, Kalloger, Steve E., Renouf, Daniel J., Connor, Ashton A, Cleary, Sean, Schaeffer, David F., Roehrl, Michael, Tsao, Ming-Sound, Gallinger, Steven, Keller, Gordon, Muthuswamy, Senthil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753163/
https://ncbi.nlm.nih.gov/pubmed/26501191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3973
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