Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions. Its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalysing the production of itaconic aci...

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Bibliographic Details
Published in:PLoS One
Main Authors: Tallam, Aravind, Perumal, Thaneer M., Antony, Paul M., Jäger, Christian, Fritz, Joëlle V., Vallar, Laurent, Balling, Rudi, del Sol, Antonio, Michelucci, Alessandro
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752512/
https://ncbi.nlm.nih.gov/pubmed/26872335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149050
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