Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction

Developing physiologically-based pharmacokinetic (PBPK) models for chemicals can be resource-intensive, as neither chemical-specific parameters nor in vivo pharmacokinetic data are easily available for model construction. Previously developed, well-parameterized, and thoroughly-vetted models can be...

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Bibliografiska uppgifter
I publikationen:PLoS Comput Biol
Huvudupphovsmän: Lu, Jingtao, Goldsmith, Michael-Rock, Grulke, Christopher M., Chang, Daniel T., Brooks, Raina D., Leonard, Jeremy A., Phillips, Martin B., Hypes, Ethan D., Fair, Matthew J., Tornero-Velez, Rogelio, Johnson, Jeffre, Dary, Curtis C., Tan, Yu-Mei
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752336/
https://ncbi.nlm.nih.gov/pubmed/26871706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004495
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