Llwytho...
Scalable Synthesis of Fmoc-Protected GalNAc-Threonine Amino Acid and T(N) Antigen via Nickel Catalysis
The highly α-selective and scalable synthesis of the Fmoc-protected GalNAc-threonine amino acid and T(N) antigen in gram scale (0.5 – 1 gram), is described. The challenging 1,2-cis-2-amino glycosidic bond is addressed through a coupling of threonine units with C(2)-N-ortho-(trifluoromethyl)benzylide...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Org Lett |
|---|---|
| Prif Awduron: | , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4752204/ https://ncbi.nlm.nih.gov/pubmed/25853273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.5b00780 |
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