Engineering a Carbohydrate-processing Transglycosidase into Glycosyltransferase for Natural Product Glycodiversification

Glycodiversification broadens the scope of natural product-derived drug discovery. The acceptor substrate promiscuity of glucosyltransferase-D (GTF-D), a carbohydrate-processing enzyme from Streptococcus mutans, was expanded by protein engineering. Mutants in a site-saturation mutagenesis library we...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Liang, Chaoning, Zhang, Yi, Jia, Yan, Wenzhao Wang, Li, Youhai, Lu, Shikun, Jin, Jian-Ming, Tang, Shuang-Yan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751530/
https://ncbi.nlm.nih.gov/pubmed/26869143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21051
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