Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons

Clinical manifestations of tetanus and botulism result from an intricate series of interactions between clostridial neurotoxins (CNTs) and nerve terminal proteins that ultimately cause proteolytic cleavage of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins and...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Beske, Phillip H., Bradford, Aaron B., Grynovicki, Justin O., Glotfelty, Elliot J., Hoffman, Katie M., Hubbard, Kyle S., Tuznik, Kaylie M., McNutt, Patrick M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Networked Cultures to Study Neurotoxin Actions on Synaptic Transmission
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751230/
https://ncbi.nlm.nih.gov/pubmed/26615023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv254
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