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Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons

Clinical manifestations of tetanus and botulism result from an intricate series of interactions between clostridial neurotoxins (CNTs) and nerve terminal proteins that ultimately cause proteolytic cleavage of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins and...

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Bibliografiske detaljer
Udgivet i:Toxicol Sci
Main Authors: Beske, Phillip H., Bradford, Aaron B., Grynovicki, Justin O., Glotfelty, Elliot J., Hoffman, Katie M., Hubbard, Kyle S., Tuznik, Kaylie M., McNutt, Patrick M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751230/
https://ncbi.nlm.nih.gov/pubmed/26615023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv254
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