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Autophagy-Induced Apoptosis in Lung Cancer Cells by a Novel Digitoxin Analog

We have synthesized a novel derivative of Digitoxin, termed “MonoD”, which demonstrates cytotoxic effects in lung cancer cells with much higher potency as compared to Digitoxin. Our data show that within 1 h of MonoD treatment, H460 cells showed increased oxidative stress, increased formation of aut...

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Detalhes bibliográficos
Publicado no:J Cell Physiol
Main Authors: Kulkarni, Yogesh M., Kaushik, Vivek, Azad, Neelam, Wright, Clayton, Rojanasakul, Yon, O’Doherty, George, Iyer, Anand Krishnan V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751068/
https://ncbi.nlm.nih.gov/pubmed/26264876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25129
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