Geneticin Stabilizes the Open Conformation of the 5′ Region of Hepatitis C Virus RNA and Inhibits Viral Replication

The aminoglycoside Geneticin (G418) is known to inhibit cell culture proliferation, via virus-specific mechanisms, of two different virus genera from the family Flaviviridae. Here, we tried to determine whether Geneticin can selectively alter the switching of the nucleotide 1 to 570 RNA region of he...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Ariza-Mateos, Ascensión, Díaz-Toledano, Rosa, Block, Timothy M., Prieto-Vega, Samuel, Birk, Alex, Gómez, Jordi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750704/
https://ncbi.nlm.nih.gov/pubmed/26621620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02511-15
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