INHIBITION OF CDK9 PREVENTS MECHANICAL INJURY-INDUCED INFLAMMATION, APOPTOSIS AND MATRIX DEGRADATION IN CARTILAGE EXPLANTS

Joint injury often leads to post-traumatic osteoarthritis (PTOA). Acute injury responses to trauma induce production of pro-inflammatory cytokines and catabolic enzymes, which promote chondrocyte apoptosis and degrade cartilage to potentiate PTOA development. Recent studies show that the rate-limiti...

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Udgivet i:Eur Cell Mater
Main Authors: Hu, Z., Yik, J.H.N., Cissell, D.D., Michelier, P.V., Athanasiou, K.A., Haudenschild, D.R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750484/
https://ncbi.nlm.nih.gov/pubmed/26859911
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