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INHIBITION OF CDK9 PREVENTS MECHANICAL INJURY-INDUCED INFLAMMATION, APOPTOSIS AND MATRIX DEGRADATION IN CARTILAGE EXPLANTS
Joint injury often leads to post-traumatic osteoarthritis (PTOA). Acute injury responses to trauma induce production of pro-inflammatory cytokines and catabolic enzymes, which promote chondrocyte apoptosis and degrade cartilage to potentiate PTOA development. Recent studies show that the rate-limiti...
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| Izdano u: | Eur Cell Mater |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4750484/ https://ncbi.nlm.nih.gov/pubmed/26859911 |
| Oznake: |
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