Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance

Obesity is characterized by a dysregulated immune system, which may causally associate with insulin resistance and type 2 diabetes. Despite widespread use of nonobese diabetic (NOD) mice, NOD with severe combined immunodeficiency (scid) mutation (SCID) mice, and SCID bearing a null mutation in the I...

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Publicado en:FASEB J
Autores principales: Friedline, Randall H., Ko, Hwi Jin, Jung, Dae Young, Lee, Yongjin, Bortell, Rita, Dagdeviren, Sezin, Patel, Payal R., Hu, Xiaodi, Inashima, Kunikazu, Kearns, Caitlyn, Tsitsilianos, Nicholas, Shafiq, Umber, Shultz, Leonard D., Lee, Ki Won, Greiner, Dale L., Kim, Jason K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2016
Materias:
Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750424/
https://ncbi.nlm.nih.gov/pubmed/26644351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-280610
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